反应详情

A mixture of 7 parts of N-[4-[1-(1H-imidazol-1-yl)-2-methylpropyl]-2-nitrophenyl]-β-oxobenzenepropanamide, 7.03 parts of potassium carbonate and 70 parts of water was stirred for 1.5 hours at reflux temperature. After cooling, the whole was treated with a hydrochloric acid solution 3N to pH 7. The product was extracted with dichloromethane (3×104 parts). The combined extracts were dried, filtered and evaporated. The residue was taken up in ethanol. The product was filtered off and dried, yielding 5.1 parts (73.0%) of 3-benzoyl-6-[1-(1H-imidazol-1-yl)-2-methylpropyl]-2(1H)-quinoxalinone, N4 -oxide monohydrate; mp. 210.0° C. (comp. 154).

1. temperatureat reflux temperature
2. temperatureAfter cooling
3. extractionThe product was extracted with dichloromethane (3×104 parts)
4. customThe combined extracts were dried
5. filtrationfiltered
6. customevaporated
7. filtrationThe product was filtered off
8. customdried