Butylamine → HCID 19818855, compound

HRID 1086389Notes

Reaction equation

HRID 1086389 reaction equation
[CH2:1]([S:3]([CH2:6][CH2:7]Cl)(=[O:5])=[O:4])[CH3:2].[CH2:9]([NH2:13])[CH2:10][CH2:11][CH3:12].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]([S:3]([CH2:6][CH2:7][NH:13][CH2:9][CH2:10][CH2:11][CH3:12])(=[O:5])=[O:4])[CH3:2]

Participants

5

Reactant 3

HCID 8007ButylamineHCID 8471TriethylamineHCID 101406Ethane, 1-chloro-2-(ethylsulfonyl)-

Product 1

HCID 19818855HCID 19818855, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
50 °C

Procedure

A solution of 15.7 g of chloroethyl ethyl sulfone in 50 ml of toluene is added dropwise within 10 min to a solution of 73 g of n-butylamine and 10.1 g of triethylamine in 100 ml of toluene at an internal temperature of 50° C. The mixture is stirred at 50° C. for 5 h and allowed to cool to room temperature, the precipitate is filtered off with suction, and the filtrate is concentrated in a rotary evaporator. The remaining yellow oil (18.7 g) is reacted without further purification.

Workup

  1. temperatureto cool to room temperature
  2. filtrationthe precipitate is filtered off with suction
  3. concentrationthe filtrate is concentrated in a rotary evaporator
  4. customThe remaining yellow oil (18.7 g) is reacted without further purification

Sources & evidence

ORD record
ord-b546acbb437146d58bfdb310fbcc1266
Source dataset
uspto-grants-1991_07
Patent number
US05030270

Reaction notes

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