Potassium Carbonate → HCID 19826066, compound

HRID 1086447Notes

Reaction equation

HRID 1086447 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH2:11])=[CH:5][CH:4]=1.C([O-])([O-])=O.[K+].[K+].[Cl:18][CH2:19][CH2:20][CH2:21][C:22]1[C:26]2[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:25]=2[O:24][N:23]=1>CN(C=O)C>[ClH:18].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][CH2:19][CH2:20][CH2:21][C:22]2[C:26]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:25]=3[O:24][N:23]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 197725Phenethylamine, p-fluoro-, hydrochlorideHCID 14837050HCID 14837050, compound

Product 1

HCID 19826066HCID 19826066, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 100 ml of dry DMF were added 2-(4-fluorophenyl)-ethylamine hydrochloride (10 g) and milled K2CO3 (20 g). After five minutes of stirring, 3-(3-chloropropyl)-5,6-dimethoxy-1,2-benzisoxazole (6.4 g) and KI (0.01 g) were added.

Sources & evidence

ORD record
ord-93e6417158b64835b3ec7c48a544056a
Source dataset
uspto-grants-1991_07
Patent number
US05030639

Reaction notes

Loading…