HCID 19818608, compound → HCID 178466802, compound

HRID 1086935Notes

Reaction equation

HRID 1086935 reaction equation
[C:1]([C:4]1[CH:40]=[CH:39][C:7]([O:8][CH2:9][CH:10]([OH:38])[CH2:11][O:12][C:13]2[CH:14]=[C:15]([NH:21][C:22]([C:24]3[N:28](CC4C=CC(OC)=CC=4)[N:27]=[N:26][N:25]=3)=[O:23])[C:16]([CH3:20])=[CH:17][C:18]=2[Br:19])=[C:6]([CH2:41][CH2:42][C:43]([F:46])([F:45])[F:44])[C:5]=1[OH:47])(=[O:3])[CH3:2]>FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>[C:1]([C:4]1[CH:40]=[CH:39][C:7]([O:8][CH2:9][CH:10]([OH:38])[CH2:11][O:12][C:13]2[CH:14]=[C:15]([NH:21][C:22]([C:24]3[NH:28][N:27]=[N:26][N:25]=3)=[O:23])[C:16]([CH3:20])=[CH:17][C:18]=2[Br:19])=[C:6]([CH2:41][CH2:42][C:43]([F:45])([F:46])[F:44])[C:5]=1[OH:47])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 19818608HCID 19818608, compound

Product 1

HCID 178466802HCID 178466802, compound

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidSolventHCID 7519AnisoleSolvent

Procedure

A solution of 6.2 g of N-{{3-{3-[4-acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-2-hydroxy-propoxy}-4-bromo-6-methyl-phenyl}}-1-(4-methoxybenzyl)-tetrazole-5-carboxamide in 130 ml of trifluoroacetic acid and 14 ml of anisole is refluxed for 30 minutes. The reaction mixture is concentrated under reduced pressure, about 200 ml of ether and 300 ml of petroleum ether are added and the crystals are filtered off. N-{{3-{3-[4-Acetyl-3-hydroxy-2-(3,3,3-trifluoropropyl)-phenoxy]-2-hydroxy-propoxy}-4-bromo-6-methyl-phenyl}}-1H-tetrazole-5-carboxamide is obtained.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure, about 200 ml of ether and 300 ml of petroleum ether
  2. additionare added
  3. filtrationthe crystals are filtered off

Sources & evidence

ORD record
ord-da52bfc2d1d344a2ab5bdaf81bdfac52
Source dataset
uspto-grants-1991_07
Patent number
US05032606

Reaction notes

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