反应详情

A mixture of 4'-acetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide (2.5 g), ammonium acetate (5.4 g) and sodium cyanoborohydride (0.96 g) in methanol (50 ml) was refluxed for 5 hours. The mixture was concentrated to dryness. The residue was dissolved in ethyl acetate, washed with water, dried, and evaporated. The residue (2.6 g) was purified by column chromatography on silica gel (70 g) eluting with a mixture of chloroform and methanol (9:1) to give a white powder of 4'-(1-aminoethyl)-2'-(2,4-difluorophenylthio)methanesulfonanilide (0.84 g).

1. temperaturewas refluxed for 5 hours
2. concentrationThe mixture was concentrated to dryness
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water
5. customdried
6. customevaporated
7. customThe residue (2.6 g) was purified by column chromatography on silica gel (70 g)
8. washeluting with a mixture of chloroform and methanol (9:1)