HCID 54186826, compound → HCID 14556350, compound

HRID 1087746Notes

Reaction equation

HRID 1087746 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH:11]=[CH:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=4)[CH2:16][CH2:15]3)=[CH:10][C:5]=2[O:4][C:3]1=[O:27]>C(OCC)(=O)C.[Ni]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][N:17]([C:20]4[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=4)[CH2:18][CH2:19]3)=[CH:10][C:5]=2[O:4][C:3]1=[O:27]

Participants

4

Reactant 1

HCID 54186826HCID 54186826, compound

Product 1

HCID 14556350HCID 14556350, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8857Ethyl AcetateSolvent

Procedure

0.01 mole of 3-methyl-6-{3-[4-(4-fluorophenyl)-1-piperazinyl]-1-propenyl}benzoxazolinone is dissolved in ethyl acetate in a 500-cm3 flask equipped with a three-way tap and a magnetic stirrer, and 0.5 g of Raney nickel is then added. The mixture is stirred under a hydrogen atmosphere at room temperature and atmospheric pressure. After the theoretical amount of hydrogen has been absorbed, the reaction medium is filtered and the filtrate is evaporated to dryness on a water bath under vacuum. The residue is crystallized in ethanol.

Workup

  1. additionis then added
  2. customAfter the theoretical amount of hydrogen has been absorbed
  3. filtrationthe reaction medium is filtered
  4. customthe filtrate is evaporated to dryness on a water bath under vacuum
  5. customThe residue is crystallized in ethanol

Sources & evidence

ORD record
ord-e782d3a7c0f94c43ae6159b5a7061d65
Source dataset
uspto-grants-1990_10
Patent number
US04960778

Reaction notes

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