Trifluoroacetic acid → HCID 14556369, compound

HRID 1087751Notes

Reaction equation

HRID 1087751 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11](=O)[CH:12]([CH3:15])[CH2:13][Br:14])=[CH:10][C:5]=2[O:4][C:3]1=[O:17].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH:12]([CH3:15])[CH2:13][Br:14])=[CH:10][C:5]=2[O:4][C:3]1=[O:17]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 14556368HCID 14556368, compound

Product 1

HCID 14556369HCID 14556369, compound

Procedure

0.03 mole of 3-methyl-6-(3-bromo-2-methylpropionyl)benzoxazolinone is dissolved in 0.3 mole of trifluoroacetic acid in a 150-cm3 flask. 0.066 mole of triethylsilane is added dropwise and with cooling. Stirring is continued for 24 hours at room temperature. The reaction mixture is poured into 5 volumes of ice-cold water. The precipitate obtained is drained, washed with water until the washing liquors are neutral, dried and recrystallized in cyclohexane.

Workup

  1. temperaturewith cooling
  2. additionThe reaction mixture is poured into 5 volumes of ice-cold water
  3. customThe precipitate obtained
  4. washwashed with water until the washing liquors
  5. customdried
  6. customrecrystallized in cyclohexane

Sources & evidence

ORD record
ord-fa92d19c905a48ac8e5a48c680f4849c
Source dataset
uspto-grants-1990_10
Patent number
US04960778

Reaction notes

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