Pyrazole → 2-Methyl-2-(pyrazol-1-yl)-butan-3one

HRID 1087772노트

반응식

Br[C:2]([C:5]([CH3:7])=[O:6])([CH3:4])[CH3:3].[NH:8]1[CH:12]=[CH:11][CH:10]=[N:9]1>>[CH3:3][C:2]([N:8]1[CH:12]=[CH:11][CH:10]=[N:9]1)([C:5](=[O:6])[CH3:7])[CH3:4]

참가 물질

반응물 2

HCID 1048Pyrazole

HCID 3449113-Bromo-3-methyl-2-butanone

생성물 1

HCID 143699442-Methyl-2-(pyrazol-1-yl)-butan-3one수율 70%

실험 절차

1 mol of methyl bromoisopropyl ketone is added dropwise at 100° C. to a melt of 4 mols of pyrazole. The reaction mixture is stirred for a further hour. Following customary working up, 2-methyl-2-(pyrazol-1-yl)-butan-3one is obtained in a yield of 70%.

출처 및 근거

ORD 기록: ord-a7d1187f40a046bca1ab0878b8c227ad
출처 데이터셋: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04960781

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