Pyrazole → 2-Methyl-2-(pyrazol-1-yl)-butan-3one

HRID 1087772Notes

Reaction equation

HRID 1087772 reaction equation
Br[C:2]([C:5]([CH3:7])=[O:6])([CH3:4])[CH3:3].[NH:8]1[CH:12]=[CH:11][CH:10]=[N:9]1>>[CH3:3][C:2]([N:8]1[CH:12]=[CH:11][CH:10]=[N:9]1)([C:5](=[O:6])[CH3:7])[CH3:4]

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 3449113-Bromo-3-methyl-2-butanone

Product 1

HCID 143699442-Methyl-2-(pyrazol-1-yl)-butan-3oneYield 70%

Procedure

1 mol of methyl bromoisopropyl ketone is added dropwise at 100° C. to a melt of 4 mols of pyrazole. The reaction mixture is stirred for a further hour. Following customary working up, 2-methyl-2-(pyrazol-1-yl)-butan-3one is obtained in a yield of 70%.

Sources & evidence

ORD record
ord-a7d1187f40a046bca1ab0878b8c227ad
Source dataset
uspto-grants-1990_10
Patent number
US04960781

Reaction notes

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