Water → HCID 14324491, compound

HRID 1088199Notes

Reaction equation

HRID 1088199 reaction equation
[C:1]([CH2:7][C:8]([O:10]CC)=O)(=O)[C:2]([CH3:5])([CH3:4])[CH3:3].O.[NH2:14][NH2:15].O>C(O)C>[C:2]([CH:1]1[CH2:7][C:8](=[O:10])[NH:15][NH:14]1)([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 962Water2×HCID 24654Hydrazine hydrate (1:1)HCID 86950Ethyl pivaloylacetate

Product 1

HCID 14324491HCID 14324491, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.0 kg of ethyl pivaloylacetate was dissolved in 2.5 liters of ethanol and 320 g of hydrazine hydrate was dropwise added thereto with cooling with water. After the completion of the dropwise addition, the whole was reacted overnight at room temperature, and then 5.0 liters of water was added thereto and stirred. The crystal which precipitated was filtered under reduced pressure, washed well with water and then with a small amount of methanol, and then dried with air. Yield: 812 g, 98.5%.

Workup

  1. additionAfter the completion of the dropwise addition
  2. customthe whole was reacted overnight at room temperature
  3. customThe crystal which precipitated
  4. filtrationwas filtered under reduced pressure
  5. washwashed well with water
  6. dry with materialwith a small amount of methanol, and then dried with air

Sources & evidence

ORD record
ord-98163ed0b34b4d469a4353bbc83d83f8
Source dataset
uspto-grants-1990_10
Patent number
US04962017

Reaction notes

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