反应详情

To a solution of sodium hydride (183 mg) and ethanethiol (0.6 ml) in DMF (15 ml) was added dropwise a solution of 3-methoxy-5-propyl-benzaldehyde (0.9 g). The reaction mixture was heated for 3 hours at 150°, quenched with NH4OAc buffer and extracted with ethyl ether. The ethyl ether layer was dried (Na2SO4) and evaporated. Flash chromatography of the residue using 30% ether in hexane afforded the title compound.

1. temperatureThe reaction mixture was heated for 3 hours at 150°
2. customquenched with NH4OAc buffer
3. extractionextracted with ethyl ether
4. dry with materialThe ethyl ether layer was dried (Na2SO4)
5. customevaporated