Methyl bromoacetate → HCID 22163068, compound

HRID 1088452Notes

Reaction equation

HRID 1088452 reaction equation
C(=O)([O-])[O-].[K+].[OH:6][C:7]1[CH:8]=[C:9]([CH:12]=[C:13]([CH2:15][CH2:16][CH3:17])[CH:14]=1)[CH:10]=[O:11].[K+].Br[CH2:20][C:21]([O:23][CH3:24])=[O:22]>C(C(C)=O)C>[CH:10]([C:9]1[CH:8]=[C:7]([CH:14]=[C:13]([CH2:15][CH2:16][CH3:17])[CH:12]=1)[O:6][CH2:20][C:21]([O:23][CH3:24])=[O:22])=[O:11]

Participants

4

Reactant 2

HCID 60984Methyl bromoacetateHCID 86744273HCID 86744273, compound

Product 1

HCID 22163068HCID 22163068, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 3-hydroxy-5-propyl-benzaldehyde potassium carbonate (0.7 g) and methyl bromoacetate (0.8 ml) in methyl ethyl ketone (6 ml) were heated at 70° for 4 hours. The reaction was filtered and evaporated. Flash chromatography of the residue using 30% ether in hexane afforded the title compound.

Workup

  1. temperaturewere heated at 70° for 4 hours
  2. filtrationThe reaction was filtered
  3. customevaporated

Sources & evidence

ORD record
ord-04a35689bf03417d811827af66fd0f0c
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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