4-Chloro-3-methylphenol → 1-Chloro-4-methoxy-2-methylbenzene

HRID 1088455Notes

Reaction equation

HRID 1088455 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[Cl:8].CI.[C:12]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:12][O:9][C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([Cl:8])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 17324-Chloro-3-methylphenolHCID 6328Methyl iodideHCID 11430Potassium Carbonate

Product 1

HCID 4581561-Chloro-4-methoxy-2-methylbenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 3-methyl-4-chlorophenol (100 g), methyl iodide (200 g) and K2CO3 (150 g) in acetone (500 ml) were refluxed 6 hours, filtered and evaporated to yield the title compound which was used as is in the next step.

Workup

  1. filtrationfiltered
  2. customevaporated

Sources & evidence

ORD record
ord-d2d2cf33358544cfae3594051f433059
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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