Sodium Hydroxide → 4-(3-(2-(7-Bromoquinolin-2-yl)ethenyl)phenoxy)butyric acid sodium salt

HRID 1088456Notes

Reaction equation

HRID 1088456 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:26]=[CH:27][CH:28]=3)[O:17][CH2:18][CH2:19][CH2:20][C:21]([O:23]CC)=[O:22])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+:30]>C(O)C.O1CCCC1>[Na+:30].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:26]=[CH:27][CH:28]=3)[O:17][CH2:18][CH2:19][CH2:20][C:21]([O-:23])=[O:22])=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 53654124Ethyl 4-(3-(2-(7-bromoquinolin-2-yl)ethenyl)phenoxy)butyrate

Product 1

HCID 703593364-(3-(2-(7-Bromoquinolin-2-yl)ethenyl)phenoxy)butyric acid sodium salt

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the ester of Example 5, Step 2, (15 g) in ethanol (200 ml) and tetrahydrofuran (200 ml) was added 2N NaOH (35 ml). The reaction was stirred at room temperature overnight and the product filtered The solid was stirred for 2 hours at room temperature in ethanol (100 ml) and filtered to give the title compound.

Workup

  1. filtrationthe product filtered The solid
  2. stirringwas stirred for 2 hours at room temperature in ethanol (100 ml)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-9ec1617a4c314222bb7ac8be3da8ff20
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

Loading…