Hydrochloric Acid → HCID 131716676, compound

HRID 1088778Notes

Reaction equation

HRID 1088778 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([N:17]3[CH2:22][CH:21]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=4)[N:19]4[N:33]=[CH:34][C:35]([C:36]#[N:37])=[C:18]34)=[O:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[ClH:38].CCOCC>C(OCC)(=O)C>[ClH:38].[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([N:17]3[CH2:22][CH:21]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:31])([F:30])[F:32])[CH:24]=4)[N:19]4[N:33]=[CH:34][C:35]([C:36]#[N:37])=[C:18]34)=[O:16])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15100986HCID 15100986, compound

Product 1

HCID 131716676HCID 131716676, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 6.6 g portion of 4-[[4-(4-fluorophenyl)-1-piperazinyl]acetyl]-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile was heated to solution in 100 ml of ethyl acetate, then cooled and acidified with 25 ml of 2.44N ethanolic hydrochloric acid. Ether was added, the solid collected, heated to boiling in 500 ml of ethanol, then cooled and the crystalline salt collected, giving 5.7 g of the desired product, mp 242°-244° C.

Workup

  1. temperaturecooled
  2. customthe solid collected
  3. temperatureheated
  4. temperaturecooled
  5. customthe crystalline salt collected

Sources & evidence

ORD record
ord-35cbf1c6a5384f19a37d3f2956d3e59f
Source dataset
uspto-grants-1990_10
Patent number
US04963553

Reaction notes

Loading…