6-Methoxy-1-Indanone → HCID 12374669, compound

HRID 1088918Notes

Reaction equation

HRID 1088918 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=[O:12])=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC.O1CCCC1>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[OH:12])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 3340366-Methoxy-1-IndanoneHCID 21226445Aluminium lithium hydride

Product 1

HCID 12374669HCID 12374669, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

33.5 g (0.2065 mol) of 6-methoxy-2,3-dihydro-1H-indenone is added in portions to a solution of 3.8 g (0.1 mol) of lithium aluminium hydride in 700 ml of dry ether and 50 ml of dry tetrahydrofuran, under an inert atmosphere with cooling. (H.0. House et al. J. Org. Chem. 35 647-51, 1970 and J. Org. Chem. 42, 2155-60, 1977).

Workup

  1. temperaturewith cooling

Sources & evidence

ORD record
ord-307fbf7560f942f7a0c7fd561c389752
Source dataset
uspto-grants-1990_10
Patent number
US04963680

Reaction notes

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