Hydrochloric Acid → HCID 15692970, compound

HRID 1090019Notes

Reaction equation

HRID 1090019 reaction equation
[CH:1]([NH:4][C:5]([C:7]1[O:11][N:10]=[C:9]([CH3:12])[C:8]=1[C:13]([O:15]C)=[O:14])=[O:6])([CH3:3])[CH3:2].[OH-].[K+].Cl>O.C(O)C>[CH:1]([NH:4][C:5]([C:7]1[O:11][N:10]=[C:9]([CH3:12])[C:8]=1[C:13]([OH:15])=[O:14])=[O:6])([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 15692969HCID 15692969, compound

Product 1

HCID 15692970HCID 15692970, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

2.6 g of the ester from Example 1 and 0.8 g of potassium hydroxide in 20 ml of water and 20 ml of ethanol are stirred for 16 hours at room temperature. Thereafter, the mixture is diluted with water, acidified with concentrated hydrochloric acid and extracted by shaking with dichloromethane. Evaporating down gives 1.8 g of 5-isopropylaminocarbonyl-3-methylisoxazole-4-carboxylic acid as colorless crystals of melting point 86°-92° C. (compound No. 1004).

Workup

  1. extractionextracted
  2. customEvaporating

Sources & evidence

ORD record
ord-a8bdeacceb86488ba3f30c61d48f5520
Source dataset
uspto-grants-1992_01
Patent number
US05080708

Reaction notes

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