Phosgene → HCID 19914186, compound

HRID 1090025Notes

Reaction equation

HRID 1090025 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([C:12]([OH:14])=O)[O:4][N:3]=1.S(Cl)([Cl:17])=O.C(Cl)(Cl)=O>CN(C)C=O>[CH3:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([C:12]([Cl:17])=[O:14])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 6371PhosgeneHCID 24386Thionyl ChlorideHCID 15692965126244-29-9

Product 1

HCID 19914186HCID 19914186, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

13.3 g of the carboxylic acid from Example b and 20 ml of thionyl chloride are refluxed in the presence of a little dimethylformamide until the evolution of gas is complete. The crude carbonyl chloride which remains in quantitative yield after evaporation is directly reacted further.

Workup

  1. customafter evaporation
  2. customis directly reacted further

Sources & evidence

ORD record
ord-7cf12ad44771402099ffffb08370bb98
Source dataset
uspto-grants-1992_01
Patent number
US05080708

Reaction notes

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