1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride → 3-Methyl-4-[1-p-chlorobenzyl-5-fluoro-3-methylindol-2-yl]butanoic acid

HRID 1090192Notes

Reaction equation

HRID 1090192 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)N)=[CH:5][CH:4]=1.[CH3:19][CH:20]([C:25](=O)[CH2:26][CH2:27][CH3:28])[CH2:21][C:22]([OH:24])=[O:23]>C(O)(C)C>[CH3:19][CH:20]([CH2:25][C:26]1[N:10]([CH2:9][C:6]2[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=2)[C:12]2[C:17]([C:27]=1[CH3:28])=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:21][C:22]([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 145912421-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochlorideHCID 199147623-Methyl-4-oxoheptanoic acid

Product 1

HCID 156787803-Methyl-4-[1-p-chlorobenzyl-5-fluoro-3-methylindol-2-yl]butanoic acid

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Following the method of Example 2, but using 1-[(4-chlorophenyl)methyl]-1-(4-fluorophenyl)hydrazine hydrochloride and 3-methyl-4-oxoheptanoic acid as the starting materials and isopropanol as the solvent, the title compound was prepared.

Sources & evidence

ORD record
ord-b33b2a36164c468695024f70a7a5f7c4
Source dataset
uspto-grants-1992_01
Patent number
US05081145

Reaction notes

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