Octanoic Acid → N-[3-(1H-Imidazol-1-yl)propyl]octanamide

HRID 1090236Notes

Reaction equation

HRID 1090236 reaction equation
[C:1]([OH:10])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[N:11]1([CH2:16][CH2:17][CH2:18][NH2:19])[CH:15]=[CH:14][N:13]=[CH:12]1>O1CCCC1>[N:11]1([CH2:16][CH2:17][CH2:18][NH:19][C:1](=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

4

Reactant 2

HCID 379Octanoic AcidHCID 787361H-Imidazole-1-propanamine

Product 1

HCID 5071006N-[3-(1H-Imidazol-1-yl)propyl]octanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The requisite starting amine was prepared as follows: reaction of n-octanoic acid and 1,1'-carbonyldi(1-imidazole) in tetrahydrofuran solution with 3-(1H-imidazol-1-yl)propanamine gave N-3-(1H-imidazolyl) propyl-n-octanamide, which upon reduction with BH3 in tetrahydrofuran solution gave N-(3-(1H-imidazol-1-yl) propyl-N-(n-octyl))amine.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-4ac876970a7f4fc58cc2b891385d2d04
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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