Hydrochloric Acid → HCID 178426313, compound

HRID 1090296Notes

Reaction equation

HRID 1090296 reaction equation
[C:1]([C:3]1[C:8](=[NH:9])[N:7]2[CH:10]=[CH:11][CH:12]=[C:13]([CH3:14])[C:6]2=[N:5][CH:4]=1)#[N:2].[N-:15]=[N+:16]=[N-:17].[Na+].Cl>CN(P(N(C)C)(N(C)C)=O)C>[CH3:14][C:13]1[C:6]([NH:5][CH:4]=[C:3]([C:8]2[NH:9][N:17]=[N:16][N:15]=2)[C:1]#[N:2])=[N:7][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 33557Sodium AzideHCID 11063074HCID 11063074, compound

Product 1

HCID 178426313HCID 178426313, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Conditions

Temperature
70 °C

Procedure

To 100 ml of HMPA were added 10.0 g (54.3 mmoles) of 3-cyano-4-imino-9-methyl-4H-pyrido[1,2-a]-pyrimidine and 3.53 g (54.3 mmoles) of sodium azide, and the reaction was carried out with stirring at 70° C. for 3 hours. After cooling, the reaction mixture was neutralized with diluted hydrochloric acid, and the crystals precipitated were collected by filtration to obtain 9.8 9 of light-brown power of 3-(3-methyl-2-pyridyl)amino-2-(1H-tetrazol-5-yl)-2-propenonitrile. Yield: 79%.

Workup

  1. temperatureAfter cooling
  2. customthe crystals precipitated
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f31d5a8b1dda4662ab87e9279406f785
Source dataset
uspto-grants-1992_01
Patent number
US05081243

Reaction notes

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