Water → 11,12-Dimethylene-13-oxa-tricyclo[7.3.1.01,7]tridecane

HRID 10906Notes

Reaction equation

CCOCC.O[CH:7]([CH2:17][C:18]([CH2:21][Si](C)(C)C)=[C:19]=[CH2:20])[CH2:8][CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:16].[Si](OS(C(F)(F)F)(=O)=O)(C)(C)C.O>CCOC(C)=O>[CH2:21]=[C:18]1[C:19](=[CH2:20])[C:10]23[O:16][CH:7]([CH2:8][CH:9]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:17]1

Participants

Conditions

Temperature: -78 °C

Procedure

1.30 mL of ether was added to 2-(2-hydroxy-4-trimethylsilanylmethyl-hexa-4,5-dienyl)-cycloheptanone (95 mg, 0.32 mmol) under nitrogen atmosphere. While stirring at −78° C., TMSOTf (58.4 μL, 0.32 mmol) was added. While stirring the reaction mixture, the reaction temperature was slowly increased to room temperature for 3 hours. The reaction mixture was stirred at room temperature for 30 minutes. After the reaction was completed, H2O was added. After stirring for about 5 minutes, the reaction mixture was diluted with EtOAc and washed with water and saturated brine. The organic layer was separated from the reaction mixture and dried with anhydrous MgSO4. The solvent was removed under reduced pressure and the remaining material was purified with column chromatography (EtOAc/n-hexane=1/6) to obtain 59 mg of the product (90%).

Workup

stirringWhile stirring the reaction mixture
temperaturethe reaction temperature was slowly increased to room temperature for 3 hours
stirringThe reaction mixture was stirred at room temperature for 30 minutes
stirringAfter stirring for about 5 minutes
washwashed with water and saturated brine
customThe organic layer was separated from the reaction mixture
dry with materialdried with anhydrous MgSO4
customThe solvent was removed under reduced pressure
customthe remaining material was purified with column chromatography (EtOAc/n-hexane=1/6)

Sources & evidence

ORD record: ord-d98115824bce4000b70e1610633eaced
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07094913B2

Reaction notes

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