Potassium Carbonate → HCID 15027611, compound

HRID 1090640Notes

Reaction equation

HRID 1090640 reaction equation
I[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].C(=O)([O-])[O-].[K+].[K+].[C:13]1([C:19]2[C:20](=[O:30])[NH:21][C:22](=[O:29])[N:23]3[CH2:28][CH2:27][CH2:26][S:25][C:24]=23)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CN(C=O)C>[CH2:2]([N:21]1[C:20](=[O:30])[C:19]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:24]2[S:25][CH2:26][CH2:27][CH2:28][N:23]2[C:22]1=[O:29])[CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 123351-IodopentaneHCID 15027610HCID 15027610, compound

Product 1

HCID 15027611HCID 15027611, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-Iodopentane (2.29 g), potassium carbonate (1.28 g) and 9-phenyl-3,4-dihydro-2H,6H-pyrimido[6,1-b][1,3]thiazine-6,8(7H)-dione (2 g) in DMF (30 ml) were stirred at 100° C. for 15 hours. The reaction solution was concentrated to dryness, and the residue was purified by column chromatography on silica gel. The obtained crude crystals were recrystalized from ethyl acetate-hexane to give colorless crystals (1.64 g, 65%).

Workup

  1. concentrationThe reaction solution was concentrated to dryness
  2. customthe residue was purified by column chromatography on silica gel
  3. customThe obtained crude crystals
  4. customwere recrystalized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-04c09b3b27404430b394532059768137
Source dataset
uspto-grants-1992_01
Patent number
US05082838

Reaction notes

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