Hydrochloric Acid → HCID 19913789, compound

HRID 1090710Notes

Reaction equation

HRID 1090710 reaction equation
[OH:1][CH:2]([CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19][CH2:18]1)[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][C:9](=[O:15])[NH:10]2.[ClH:31]>C(O)C.C(OC(C)C)(C)C>[ClH:31].[OH:1][CH:2]([CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19][CH2:18]1)[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][C:9](=[O:15])[NH:10]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15677028HCID 15677028, compound

Product 1

HCID 19913789HCID 19913789, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 7914Diisopropyl EtherSolvent

Procedure

3,4-Dihydro 5-[2-hydroxy-3-(4-(tert-butoxycarbonylamino)-1-piperidyl)propoxy]carbostyril (1 g, m.p. 138° C.) was dissolved in ethanol (10 mL) and acidified with hydrochloric acid-saturated ethanol. The resulting mixture was diluted with 2 volumes of diisopropylether and kept at room temperature for 24 hours. A white precipitate was collected by filtration and washed with ether to give 1,1 g of 3,4-dihydro-5-[2-hydroxy-3-(4-(tert-butoxycarbonylamino)-1-piperidyl)propoxy]carbostyril hydrochloride, m.p. 195°-197° C. (dec.).

Workup

  1. filtrationA white precipitate was collected by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-f3a1b73a887d4c698dd66234391a4b58
Source dataset
uspto-grants-1992_01
Patent number
US05082847

Reaction notes

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