反应详情

温度

0 °C

A solution of 10.7g (71.25 mmoles) of 2-hydroxy-4-methylacetophenone and 31.24g (214 mmoles) of diethyloxalate in 25 ml of ethanol is added dropwise to a solution of sodium ethoxide (formed by adding 6.55g of sodium metal to 120 ml of ethanol). The mixture is refluxed for 4 hours, cooled to 0° C. and diluted with 500 ml of ether. The precipitate which forms on standing overnight is filtered off and redissolved in water and the solution acidified (pH approximately 1) with 1N hydrochloric acid. The mixture is extracted with ethyl acetate which is dried and concentrated in vacuo. The residue is dissolved in 100 ml of ethanol and 3 ml of concentrated hydrochloric acid. This solution is refluxed for 1.5 hours, then concentrated in vacuo. The residue is poured into ice water and the precipitate which formed on standing overnight is filtered off and dissolved in ethyl acetate. The ethyl acetate solution is dried and concentrated in vacuo. The residue is purified by flash column chromatography through silica gel and recrystallization from ether/hexanes to give 8.75g of 2-carboethoxy-7-methyl-4-oxo-4H-1-benzopyran as a white crystalline solid having an m.p. of 62°-4° C.

1. temperatureThe mixture is refluxed for 4 hours
2. filtrationis filtered off
3. dissolutionredissolved in water
4. extractionThe mixture is extracted with ethyl acetate which
5. customis dried
6. concentrationconcentrated in vacuo
7. dissolutionThe residue is dissolved in 100 ml of ethanol
8. temperatureThis solution is refluxed for 1.5 hours
9. concentrationconcentrated in vacuo
10. additionThe residue is poured into ice water
11. customthe precipitate which formed
12. waiton standing overnight
13. filtrationis filtered off
14. dissolutiondissolved in ethyl acetate
15. dry with materialThe ethyl acetate solution is dried
16. concentrationconcentrated in vacuo
17. customThe residue is purified by flash column chromatography through silica gel and recrystallization from ether/hexanes