反应详情

A solution of 36% HCl (9.12 g, 15 eq.) and n-propanol (9.0 ml) was added to 5-amino-3-trifluoromethylisoxazole (0.91 g, 6.0 mmole) from Preparation 1 and heated at reflux for 23 hours. The reaction mixture was cooled, extracted with methylene chloride and distilled under reduced pressure to give 0.006 g (0.7%) of the titled compound as a colorless liquid, b.p. 35°-37° C./1.4 mmHg. This product was thought to be the keto form or a mixture of the keto and enol form by NMR and IR.

1. temperatureheated
2. temperatureat reflux for 23 hours
3. temperatureThe reaction mixture was cooled
4. extractionextracted with methylene chloride
5. distillationdistilled under reduced pressure