Hydrochloric Acid → HCID 19913992, compound

HRID 1090842Notes

Reaction equation

HRID 1090842 reaction equation
[OH:1][CH:2]([CH2:32][OH:33])[CH2:3][O:4][C:5]1[N:6]=[N:7][C:8]([NH:11][NH:12][C:13](C2C=CC=CC=2)([C:20]2C=CC=CC=2)[C:14]2C=CC=CC=2)=[CH:9][CH:10]=1.[ClH:34]>O1CCCC1>[ClH:34].[OH:1][CH:2]([CH2:32][OH:33])[CH2:3][O:4][C:5]1[N:6]=[N:7][C:8]([NH:11][N:12]=[C:13]([CH3:14])[CH3:20])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15020501HCID 15020501, compound

Product 1

HCID 19913992HCID 19913992, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (RS)-3-(2,3-Dihydroxypropoxy)-6-(2-triphenylmethylhydrazino)pyridazine (3.2 g) in tetrahydrofuran (80 ml), conc. hydrochloric acid (2 ml) was added. After stirring at room temperature for 15 minutes the solution was concentrated under vacuum to small volume and diluted with acetone (50 ml). After stirring at room temperature for 30 minutes and then at 0° C. for 1 hour the precipitate was collected to yield 1.4 g of the title compound, identical to that obtained in Example 14.

Workup

  1. concentrationwas concentrated under vacuum to small volume
  2. additiondiluted with acetone (50 ml)
  3. stirringAfter stirring at room temperature for 30 minutes
  4. customat 0° C. for 1 hour the precipitate was collected

Sources & evidence

ORD record
ord-7c06a8086c76457c9de134d32546a5b4
Source dataset
uspto-grants-1992_01
Patent number
US05082939

Reaction notes

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