反应详情

A mixture of 4-(1-hydroxytridecyl)-2-trimethylsilylfuran (318.5 mg, 0.9 mmol), sodium hydride (60% dispersion in oil; 150 mg, 3.8 mmol) and iodomethane (0.29 ml, 4.7 mmol) in tetrahydrofuran (7 ml) was refluxed for 16 hours. On cooling, the mixture was diluted with ethyl ether (20 ml), quenched with methanol (2 ml) and washed with water. Evaporation of the dried (magnesium sulfate) organic phase gave a deep yellow oil, identified as 4-(1-methoxytridecyl)-2-trimethylsilyfuran.

1. temperaturewas refluxed for 16 hours
2. temperatureOn cooling
3. customquenched with methanol (2 ml)
4. washwashed with water
5. customEvaporation of the
6. dry with materialdried (magnesium sulfate) organic phase
7. customgave a deep yellow oil