反应详情

Sodium metal (0.31 g, 0.014 mol) was dissolved in absolute EtOH (20 mL). To this mixture was added diethyl malonate (2.2 g, 0.014 mol) in EtOH (5 mL) and the above 7-oxa-10-thiadodecyl bromide (3 g, 0.011 mol) in EtOH (5 mL) at room temperature. The reaction mixture was refluxed for 5 h. After evaporation of the solvent, the residue was dissolved in ethyl acetate (120 mL). The organic phase was washed with water (2×30 mL), brine (30 mL), and dried (Na2SO4). The crude product was purified by Kugelrohr distillation to give ethyl 2-ethoxycarbonyl9-oxa-12-thiatetradecanoate (2.3 g, 58%); bp 122° C.-128° C./0.04 torr; NMR: 1.27 (6H, t, J=7 Hz), 3.3-3.7 (5H, m), and 4.17 ppm (4H, q, J=7 Hz), 1.2-1.9 (10H, m), 2.59 (2H, q, J=7 Hz), 2.68 (2H, t, J=7 Hz), 3.1-3.7 (5H, m), and 4.17 ppm (4H, q, J=7 Hz).

1. customat room temperature
2. temperatureThe reaction mixture was refluxed for 5 h
3. customAfter evaporation of the solvent
4. dissolutionthe residue was dissolved in ethyl acetate (120 mL)
5. washThe organic phase was washed with water (2×30 mL), brine (30 mL)
6. dry with materialdried (Na2SO4)
7. distillationThe crude product was purified by Kugelrohr distillation