Hydrogen Peroxide → HCID 178522599, compound

HRID 1091019Notes

Reaction equation

HRID 1091019 reaction equation
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=S)[NH:12][C:13](=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:3].CO.OO>N>[O:3]=[C:2]1[C:4]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:10][C:11]([NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:1]1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 887MethanolHCID 730237HCID 730237, compound

Product 1

HCID 178522599HCID 178522599, compoundYield 40.1%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

To a stirred mixture of 4.5 g of the above benzamide in a mixture of 120 ml of methanolic ammonia plus 100 ml of methanol, was added dropwise, 3.6 ml of 30% hydrogen peroxide. This mixture was stirred overnight, the solid collected, partially dissolved in 500 ml of hot acetonitrile and filtered. The filtrate was chilled and the solid collected, giving 1.6 g of the desired product as white crystals, mp 227°-228° C. (dec.).

Workup

  1. additionwas added dropwise
  2. customthe solid collected
  3. dissolutionpartially dissolved in 500 ml of hot acetonitrile
  4. filtrationfiltered
  5. temperatureThe filtrate was chilled
  6. customthe solid collected

Sources & evidence

ORD record
ord-22a1a186ecf44bc0a78d598790f97f74
Source dataset
uspto-grants-1992_01
Patent number
US05084457

Reaction notes

Loading…