Hydrochloric Acid → HCID 57988651, compound

HRID 1091210Notes

Reaction equation

HRID 1091210 reaction equation
O[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[CH2:11]=[O:12].[Cl-:13].[Ca+2].[Cl-].Cl>C(Cl)Cl>[Cl:13][CH2:11][O:12][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 779362-IndanolHCID 5284359Calcium Chloride

Product 1

HCID 57988651HCID 57988651, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 134 g of 2-hydroxyindane, 36.1 g of paraformaldehyde, 200 g of calcium chloride, and 1200 g of methylene chloride was agitated. Into the mixture was dropped 239 g of a concentrated hydrochloric acid at room temperature for 3 hours, and then the reaction mixture was agitated for 16 hours. After separated an organic layer from the mixture, the solvent was removed by distillation to obtain 183 g of chloromethyl(2-indanyl)ether as an oily matter.

Workup

  1. stirringthe reaction mixture was agitated for 16 hours
  2. customAfter separated an organic layer from the mixture
  3. customthe solvent was removed by distillation

Sources & evidence

ORD record
ord-8fcea9b2b3484c78947b2974da5cd3bc
Source dataset
uspto-grants-2012_03
Patent number
US08129086B2

Reaction notes

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