Hydrochloric Acid → HCID 178479720, compound

HRID 1091530Notes

Reaction equation

HRID 1091530 reaction equation
[N:1]1[CH2:2][CH2:3][N:4]2[C:13]=1[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=[C:5]2[NH:14][C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.[ClH:23].O1CCOCC1>O1CCCC1>[ClH:23].[N:1]1[CH2:2][CH2:3][N:4]2[C:13]=1[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=[C:5]2[NH:14][C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178522485HCID 178522485, compound

Product 1

HCID 178479720HCID 178479720, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of N-(2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (150 mg, 0.515 mmol) in tetrahydrofuran (4 ml) at 0° C. was added a 4N solution of hydrochloric acid in 1,4-dioxane (2 ml, 8 mmol). The mixture was stirred at room temperature for 1 h, and concentrated under reduced pressure. The resulting residue was triturated with diethyl ether. The resulting precipitate was collected by filtration, washed with ethyl ether, and dried under reduced pressure to give N-(2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide hydrochloride (192 mg, quantitative).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting residue was triturated with diethyl ether
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with ethyl ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-142f21886ed64bd5acb470e298062e38
Source dataset
uspto-grants-2012_03
Patent number
US08129386B2

Reaction notes

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