Hydrochloric Acid → HCID 66594108, compound

HRID 1091544Notes

Reaction equation

HRID 1091544 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:13]=1[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=[C:5]2[NH:14][C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.[ClH:23]>CO.O1CCOCC1>[ClH:23].[N:1]1[CH:2]=[CH:3][N:4]2[C:13]=1[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=[C:5]2[NH:14][C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57599804HCID 57599804, compound

Product 1

HCID 66594108HCID 66594108, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N-imidazo[1,2-c]quinazolin-5-ylnicotinamide (40 mg, 0.14 mmol) in methanol (20 ml) was added a 4N solution of HCl in 1,4dioxane (0.5 ml). The mixture was concentrated under reduced pressure. The resulting solid was collected by filtration, washed with tetrahydrofurane and dried under reduced pressure to give N-imidazo[1,2-c]quinazolin-5-ylnicotinamide hydrochloride (40 mg, 89% yield) as a white solid.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with tetrahydrofurane
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-ac3272be2c1140c19bc875face40ef49
Source dataset
uspto-grants-2012_03
Patent number
US08129386B2

Reaction notes

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