Potassium Cation → 5-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile

HRID 109185Notes

Reaction equation

[C-:19]#[N:20].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:18])[CH2:9][CH2:10][C:11]3([O:12][CH2:13][CH2:14][O:15]3)[CH2:16][CH2:17]2)[cH:6][n:7]1.[K+:21].[O:22]=[CH:23][N:24]([CH3:25])[CH3:26]>>[c:2]1([C:19]#[N:20])[cH:3][cH:4][c:5]([C:8]2([OH:18])[CH2:9][CH2:10][C:11]3([O:12][CH2:13][CH2:14][O:15]3)[CH2:16][CH2:17]2)[cH:6][n:7]1

Participants

Reactant 4

HCID 813Potassium Cation

HCID 5975Cyanide

HCID 6228Dimethylformamide

HCID 595560478-(6-Fluoropyridin-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

Product 1

HCID 667870965-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile

Sources & evidence

ORD record: ord-eae3c8e8b2d5432a91b6c1507c088775
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…