Hydrochloric Acid → HCID 11560993, compound

HRID 1091853Notes

Reaction equation

HRID 1091853 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:33])[C:7]=1[NH:8][C:9]([C:11]1[C:16]2[C:17]3[CH2:18][N:19](C(OC(C)(C)C)=O)[CH2:20][CH2:21][C:22]=3[O:23][C:15]=2[C:14]([O:31][CH3:32])=[CH:13][CH:12]=1)=[O:10].Cl>C(OCC)C.C(OCC)(=O)C>[ClH:1].[Cl:33][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[NH:8][C:9]([C:11]1[C:16]2[C:17]3[CH2:18][NH:19][CH2:20][CH2:21][C:22]=3[O:23][C:15]=2[C:14]([O:31][CH3:32])=[CH:13][CH:12]=1)=[O:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66592541HCID 66592541, compound

Product 1

HCID 11560993HCID 11560993, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

To the suspension of N-(3,5-dichloropyridin-4-yl)-2-(tert-butyloxycarbonyl)-6-methoxy-1,2,3,4-tetrahydro[1]benzofuro[3,2-c]pyridine-9-carboxamide (from step 4) (600 mg) in dry diethyl ether (10 ml), ethyl acetate saturated with HCl (4 ml) was added and stirred overnight. Reaction mixture was concentrated and the residue obtained was stirred in dry diethyl ether and filtered. The solid obtained was further purified by refluxing in isopropanol overnight. Yield=400 mg

Workup

  1. additionwas added
  2. customReaction mixture
  3. concentrationwas concentrated
  4. customthe residue obtained
  5. filtrationfiltered
  6. customThe solid obtained
  7. customwas further purified
  8. temperatureby refluxing in isopropanol overnight

Sources & evidence

ORD record
ord-22753b81fbaf437d8a80f24843b18e78
Source dataset
uspto-grants-2012_03
Patent number
US08129401B2

Reaction notes

Loading…