Hydrochloric Acid → HCID 11697743, compound

HRID 1091855Notes

Reaction equation

HRID 1091855 reaction equation
[CH3:1][O:2][C:3]1[C:15]2[N:14]([CH3:16])[C:13]3[C:12](=[O:17])[N:11]([CH3:18])[CH2:10][CH2:9][C:8]=3[C:7]=2[C:6]([C:19]([O:21]C2C=CC([N+]([O-])=O)=CC=2)=O)=[CH:5][CH:4]=1.[NH2:31][C:32]1[C:37]([Cl:38])=[CH:36][N:35]=[CH:34][C:33]=1[Cl:39].[H-].[Na+].Cl>>[Cl:39][C:33]1[CH:34]=[N:35][CH:36]=[C:37]([Cl:38])[C:32]=1[NH:31][C:19]([C:6]1[C:7]2[C:8]3[CH2:9][CH2:10][N:11]([CH3:18])[C:12](=[O:17])[C:13]=3[N:14]([CH3:16])[C:15]=2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:21]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 898884-Amino-3,5-dichloropyridineHCID 66592918HCID 66592918, compound

Product 1

HCID 11697743HCID 11697743, compound

Procedure

To a solution of p-nitrophenyl ester (from step 6) (1 mmol) and 4-amino-3,5-dichloropyridine (1.2 mmol), NaH (1.2 mmol) was added at once and the reaction mixture was stirred for 18 h at room temperature it was then acidified with few drops of 6N HCl. Desired amide precipitated out that was filtered and dried (80-90%).

Workup

  1. customDesired amide precipitated out
  2. filtrationthat was filtered
  3. customdried (80-90%)

Sources & evidence

ORD record
ord-402237822beb4b14b6e77a750663c1ad
Source dataset
uspto-grants-2012_03
Patent number
US08129401B2

Reaction notes

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