反应详情

To a well stirred suspension of 7-Hydroxy-2-methylbenzo[b]furan-4-carbaldehyde (39.0 g, 0.221 moles) in DMF (200 mL) was added powdered potassium carbonate (76.0 g, 0.555 moles) and cyclopentyl bromide (43.0 g, 0.287 moles) and stirred at 70-75° C. for 4-5 hrs. The reaction mixture was then cooled to room temperature and water (1.5 L) was added to it. The organic material separated was extracted with ethyl acetate (3×100 ml). The combined organic layers were washed with water ((2×500 mL) and dried over anhydrous sodium sulfate. Removal of solvent under vacuo gave product (55.0 g) as light brown viscous oil.

1. stirringstirred at 70-75° C. for 4-5 hrs
2. customThe organic material separated
3. extractionwas extracted with ethyl acetate (3×100 ml)
4. washThe combined organic layers were washed with water ((2×500 mL)
5. dry with materialdried over anhydrous sodium sulfate
6. customRemoval of solvent under vacuo