Diisopropylethylamine → HCID 11627685, compound

HRID 1091983Notes

Reaction equation

HRID 1091983 reaction equation
Cl.[F:2][C:3]([F:22])([O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:11][CH:10]=1)[C:4]([F:7])([F:6])[F:5].C(N(C(C)C)CC)(C)C.[CH2:32]([C@@:34]1([CH2:41][S:42](Cl)(=[O:44])=[O:43])[C:38](=[O:39])[NH:37][C:36](=[O:40])[NH:35]1)[CH3:33]>ClCCl>[CH2:32]([C@:34]1([CH2:41][S:42]([N:17]2[CH2:18][CH2:19][CH:14]([O:13][C:12]3[CH:11]=[CH:10][C:9]([O:8][C:3]([F:2])([F:22])[C:4]([F:7])([F:6])[F:5])=[CH:21][CH:20]=3)[CH2:15][CH2:16]2)(=[O:43])=[O:44])[NH:35][C:36](=[O:40])[NH:37][C:38]1=[O:39])[CH3:33]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 55280267HCID 55280267, compoundHCID 86624651HCID 86624651, compound

Product 1

HCID 11627685HCID 11627685, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-[4-(pentafluoroethoxy)phenoxy]piperidine hydrochloride (0.17 g) and diisopropylethylamine (0.19 mL) in dichloromethane (100 mL) was added [(4S)-4-ethyl-2,5-dioxoimidazolidin-4-yl]methanesulfonyl chloride (0.13 g). The reaction was stirred at ambient temperature for 18 hours.

Sources & evidence

ORD record
ord-9f00ab9de53f45cf8941d22378b2b94d
Source dataset
uspto-grants-2012_03
Patent number
US08129412B2

Reaction notes

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