反应详情

温度

40 °C

To a solution of acetophenone (10 g) in 50 mL methanol, a solution of sodium cyanide (12.23 g) and methylamine.HCl (16.71 g) in 50 mL water was added slowly at room temp. The reaction mixture was heated at 40° C. for 2 h and then at room temperature for 18 h and was monitored by TLC. After completion, the reaction mixture was extracted with 3×100 mL dichloromethane. The organic layer was then dried over Na2SO4 and concentrated to afford the desired 2-methylamino-2-phenyl-propionitrile (12.5 g) which was used in the next step without further purification.

1. extractionAfter completion, the reaction mixture was extracted with 3×100 mL dichloromethane
2. dry with materialThe organic layer was then dried over Na2SO4
3. concentrationconcentrated