Hydrogen Bromide → HCID 66588691, compound

HRID 1092729Notes

Reaction equation

HRID 1092729 reaction equation
Cl.C[O:3][C:4]1[C:9]2[CH2:10][C@H:11]3[C@H:16]([CH2:17][C:8]=2[CH:7]=[CH:6][C:5]=1[O:18]C)[NH:15][CH2:14][CH2:13][CH2:12]3.[BrH:20]>>[BrH:20].[NH:15]1[C@@H:16]2[C@H:11]([CH2:10][C:9]3[C:4]([OH:3])=[C:5]([OH:18])[CH:6]=[CH:7][C:8]=3[CH2:17]2)[CH2:12][CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 66588714HCID 66588714, compound

Product 1

HCID 66588691HCID 66588691, compound

Conditions

Temperature
170 °C

Procedure

Intermediate III (16 mg) was placed in a microwave reactor vial and 48% HBr (1 mL) was added. The reactor was sealed, and the mixture was stirred at 170° C. for 1 h under microwave irradiation. The precipitated product was filtered off and dried in vacuo. Yield of example 2a2: 11 mg as a solid. LC/MS (method 17): RT 1.27 min, ELSD 88%, UV 75.1%, MH+: 220.1.

Workup

  1. customThe reactor was sealed
  2. filtrationThe precipitated product was filtered off
  3. customdried in vacuo
  4. customRT 1.27 min, ELSD 88%, UV 75.1%, MH+

Sources & evidence

ORD record
ord-befc690242f6469a821f4a1c13a50223
Source dataset
uspto-grants-2012_03
Patent number
US08129530B2

Reaction notes

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