Water → tert-Butyl 4-(acetylthio)piperidine-1-carboxylate

Temperature

65 °C

Crude 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester was dissolved in 200 ml DMF, and potassium thioacetate (18.5 g, 162 mmol) was added. The mixture was stirred overnight under a nitrogen atmosphere at about 65° C. The reaction mixture solidified overnight, and after it was cooled to room temperature, 250 ml water and 250 ml TBME was added, and the mixture was stirred for 10 minutes. The layers were separated, and the aqueous layer was extracted with 200 ml TBME. The combined organic layers were washed with water (2×250 ml) and saturated aqueous NaCl solution (150 ml), dried over sodium sulfate, filtered, and evaporated to dryness (30.3 g, 94%) to give a dark-brown oil identified as the product by 1H-NMR, which was used without purification in the next step.

1. temperatureThe reaction mixture solidified overnight, and after it was cooled to room temperature
2. stirringthe mixture was stirred for 10 minutes
3. customThe layers were separated
4. extractionthe aqueous layer was extracted with 200 ml TBME
5. washThe combined organic layers were washed with water (2×250 ml) and saturated aqueous NaCl solution (150 ml)
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customevaporated to dryness (30.3 g, 94%)
9. customto give a dark-brown oil
10. customwas used without purification in the next step

ORD record

ord-8b4354b794144167b4fa9b51b8224315

Source dataset

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08129546B2