Trifluoroacetic acid → HCID 57424681, compound

HRID 1093228Notes

Reaction equation

HRID 1093228 reaction equation
[CH3:1][N:2]([CH3:52])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:51])[NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[N:26]=[C:25]4[N:27]([CH2:30][C:31]([F:34])([F:33])[F:32])[N:28]=[CH:29][C:24]4=[C:23]([N:35]4[CH:40]5[CH2:41][N:42](C(OC(C)(C)C)=O)[CH2:43][CH:36]4[CH2:37][O:38][CH2:39]5)[N:22]=3)=[CH:17][CH:16]=2)=[CH:8][CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[CH:36]12[N:35]([C:23]3[N:22]=[C:21]([C:18]4[CH:19]=[CH:20][C:15]([NH:14][C:13]([NH:12][C:9]5[CH:8]=[CH:7][C:6]([O:5][CH2:4][CH2:3][N:2]([CH3:52])[CH3:1])=[CH:11][CH:10]=5)=[O:51])=[CH:16][CH:17]=4)[N:26]=[C:25]4[N:27]([CH2:30][C:31]([F:34])([F:32])[F:33])[N:28]=[CH:29][C:24]=34)[CH:40]([CH2:41][NH:42][CH2:43]1)[CH2:39][O:38][CH2:37]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 57424705HCID 57424705, compound

Product 1

HCID 57424681HCID 57424681, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 9-(6-(4-(3-(4-(2-(dimethylamino)ethoxy)phenyl)ureido)phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane-7-carboxylate.TFA (174 mg) in dichloromethane (5 mL) was treated with trifluoroacetic acid (1 mL). After concentration, the residue was purified by reverse-phase high performance liquid chromatography to provide, after concentration, the title compound. MS (ES+): 626.3 (M+H)+

Workup

  1. concentrationAfter concentration
  2. customthe residue was purified by reverse-phase high performance liquid chromatography
  3. customto provide
  4. concentrationafter concentration

Sources & evidence

ORD record
ord-82b0d0409e644406997315f483bea657
Source dataset
uspto-grants-2012_03
Patent number
US08129371B2

Reaction notes

Loading…