反应详情

A urea formation procedure similar to that used for the synthesis of ethyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-(3-ethylureido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate is used, utilizing 4-(1-pyrrolidinyl)-aniline as the aniline component. (41%, MS=539.3 (M+H))A urea formation procedure similar to that used for the synthesis of ethyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-(3-ethylureido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate is used, utilizing 2-(4-aminophenoxy)ethanol (prepared by the reduction of 2-(4-nitrophenoxy)ethanol in ethyl acetate and methanol with palladium on carbon and hydrogen gas) as the aniline component. (2%, MS=530.4 (M+H))