Urea → HCID 178518411, compound

HRID 1093294Notes

Reaction equation

HRID 1093294 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=[O:8].N[C:11](N)=[O:12].[OH-].[Na+]>C(O)(=O)C>[N:1]1[C:2]2[CH:6]=[CH:5][S:4][C:3]=2[C:7]([OH:8])=[N:9][C:11]=1[OH:12]

Participants

5

Reactant 3

HCID 1176Urea2×HCID 14798Sodium HydroxideHCID 5189933-Aminothiophene-2-carboxamide

Product 1

HCID 178518411HCID 178518411, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

50 mg (0.35 mmol) 3-amino-2-aminocarbonyl-thiophene is covered with urea. The urea is heated until molten. After 5 minutes of heating, the molten mixture is poured into 1 N NaOH (2 mL). Acetic acid is added to neutralize the mixture (pH 7) and the resulting white precipitate is collected. Yield: 39 mg (0.23 mmol, 66%).

Workup

  1. temperatureAfter 5 minutes of heating
  2. customthe resulting white precipitate is collected

Sources & evidence

ORD record
ord-f43c7639e98c4c10b3a773188ddd6977
Source dataset
uspto-grants-2012_03
Patent number
US08129371B2

Reaction notes

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