Methanol → HCID 65100083, compound

HRID 1093480Notes

Reaction equation

HRID 1093480 reaction equation
[OH2:1].[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8](O)(=O)=O)=CC=1.C(N([CH2:18][CH3:19])CC)C.[CH3:20]O>>[CH3:12][C:2]1[S:8][CH:5]=[C:6]([CH:20]([OH:1])[CH2:18][CH3:19])[CH:7]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 8471TriethylamineHCID 521998p-Toluenesulfonic acid monohydrate

Product 1

HCID 65100083HCID 65100083, compound

Procedure

A solution of compound 83-2 (1.47 g) and p-toluenesulfonic acid monohydrate (10.0 mg) in methanol (20 ml) was stirred at room temperature for 17 hr. Triethylamine (0.10 ml) was added to the reaction mixture, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=99:1-70:30) to give the object product (0.73 g) as a brown oil.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=99:1-70:30)

Sources & evidence

ORD record
ord-1c6cf3bb3c7f4695b062a8781e32e0ee
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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