Hydrochloric Acid → HCID 66594027, compound

HRID 1093509Notes

Reaction equation

C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]=[CH:27][C:28]3[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=3)=[C:20]([C:35]([F:38])([F:37])[F:36])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:40]>C(O)C>[ClH:40].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]=[CH:27][C:28]2[CH:29]=[CH:30][C:31]([CH3:34])=[CH:32][CH:33]=2)=[C:20]([C:35]([F:36])([F:37])[F:38])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]

Participants

Conditions

Temperature: 50 °C

Procedure

Compound 102-3 (550 mg) was dissolved in ethanol (18 ml), concentrated hydrochloric acid (3.5 ml) was added, and the mixture was stirred at 50° C. for 4 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether and methanol to give the object product (180 mg) as a white powder.

Workup

concentrationThe reaction mixture was concentrated
washthe residue was washed with diethyl ether and methanol

Sources & evidence

ORD record: ord-a54b6ec73cb14f0790ca853ee354aafa
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129361B2

Reaction notes

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