Dimethylformamide → N-(2,2-Dimethoxyethyl)-3-(2-fluoro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-(2,2,2-trifluoroethyl)propanamide

HRID 109389Notes

Reaction equation

HRID 109389 reaction equation
[CH3:62][O:63][CH:64]([CH2:65][NH:66][CH2:67][C:68]([F:69])([F:70])[F:71])[O:72][CH3:73].[CH3:74][CH2:75][N:76]([CH2:77][CH3:78])[CH2:79][CH3:80].[F:25][c:26]1[c:27]([CH2:28][CH2:29][O:30][CH2:31][CH2:32][C:33](=[O:34])[OH:35])[cH:36][cH:37][cH:38][c:39]1[CH2:40][N:41]1[CH2:42][CH2:43][C:44]2([CH2:45][N:46]([C:50](=[O:51])[c:52]3[n:53][c:54]([CH:57]([CH3:58])[CH3:59])[s:55][cH:56]3)[CH2:47][CH2:48][O:49]2)[CH2:60][CH2:61]1.[O:81]=[CH:82][N:83]([CH3:84])[CH3:85].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[F:25][c:26]1[c:27]([CH2:28][CH2:29][O:30][CH2:31][CH2:32][C:33](=[O:34])[N:66]([CH2:65][CH:64]([O:63][CH3:62])[O:72][CH3:73])[CH2:67][C:68]([F:69])([F:70])[F:71])[cH:36][cH:37][cH:38][c:39]1[CH2:40][N:41]1[CH2:42][CH2:43][C:44]2([CH2:45][N:46]([C:50](=[O:51])[c:52]3[n:53][c:54]([CH:57]([CH3:58])[CH3:59])[s:55][cH:56]3)[CH2:47][CH2:48][O:49]2)[CH2:60][CH2:61]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 58168586Ethanamine,N-(2,2-dimethoxyethyl)-2,2,2-trifluoro-HCID 669637983-(2-Fluoro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid

Product 1

HCID 58168607N-(2,2-Dimethoxyethyl)-3-(2-fluoro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-(2,2,2-trifluoroethyl)propanamide

Sources & evidence

ORD record
ord-f262dd15b3c844f2ae7e0fb72786b032
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…