Sodium Bicarbonate → HCID 11590986, compound

HRID 1094049Notes

Reaction equation

HRID 1094049 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[C:18]2[C:17](=[O:19])[N:16]([CH3:20])[C:15](=[O:21])[N:14]([CH3:22])[C:13]=2[N:12]=[C:11](Cl)[C:10]=1[C:24]#[N:25].[C:26]([O-:29])(O)=O.[Na+]>CO.N1CCOCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[C:18]2[C:17](=[O:19])[N:16]([CH3:20])[C:15](=[O:21])[N:14]([CH3:22])[C:13]=2[N:12]=[C:11]([N:12]2[CH2:13][CH2:26][O:29][CH2:10][CH2:11]2)[C:10]=1[C:24]#[N:25]

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 11683267HCID 11683267, compound

Product 1

HCID 11590986HCID 11590986, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8083MorpholineSolvent

Conditions

Temperature
80 °C

Procedure

An amount of 50 mg (0.117 mmole) of 47a was dissolved in 500 μL, of MeOH, 1 ml of morpholine and 512 mg (6.203 mmole) of NaHCO3. The mixture was heated to 80° C. for 1 hr to give 5-(2-Bromo-5-fluoro-phenyl)-1,3-dimethyl-7-morpholin-4-yl-2,4-dioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (47b).

Sources & evidence

ORD record
ord-1a1490b964a4402f9f255dea80213c13
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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