4-Cyanobenzaldehyde → HCID 25115756, compound

HRID 1094053Notes

Reaction equation

HRID 1094053 reaction equation
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1)=O.[NH2:11][C:12]1[N:17]([CH3:18])[C:16](=[O:19])[N:15]([CH3:20])[C:14](=[O:21])[CH:13]=1>>[NH2:11][C:12]1[C:13]([CH2:14][NH2:15])=[C:1]([C:3]2[CH:10]=[CH:9][C:6]([CH2:7][NH2:8])=[CH:5][CH:4]=2)[C:13]2[C:14](=[O:21])[N:15]([CH3:20])[C:16](=[O:19])[N:17]([CH3:18])[C:12]=2[N:11]=1

Participants

3

Reactant 2

HCID 660424-CyanobenzaldehydeHCID 811526-Amino-1,3-dimethyluracil

Product 1

HCID 25115756HCID 25115756, compound

Procedure

The synthesis of title compounds started from 4-formylbenzonitrile and 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, according to the procedures described in the synthesis of Compound 56. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.06 (s, 3H) 3.53 (s, 3H) 3.56 (d, J=5.56 Hz, 2H) 4.12 (d, J=5.56 Hz, 2H) 7.22 (d, J=7.83 Hz, 2H) 7.49 (m, 4H) 7.92 (br. s., 2H) 8.37 (br. s., 2H) MS [m+H] MS [m+H] calc'd C17H20N6O2 341.38; found 341.4.

Workup

  1. customThe synthesis of title compounds

Sources & evidence

ORD record
ord-33a261fef57a443d964e4179cce0db41
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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