p-Toluidine → HCID 58007505, compound

HRID 1094347Notes

Reaction equation

HRID 1094347 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[N:16]=[CH:15][C:14]([CH2:17][C:18]#N)=[CH:13][CH:12]=1>>[C:2]1([CH3:1])[CH:8]=[CH:7][C:5]([NH:6][CH2:18][CH2:17][C:14]2[CH:15]=[N:16][C:11]([C:10]([F:21])([F:9])[F:20])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7813p-ToluidineHCID 508511273-Pyridineacetonitrile, 6-(trifluoromethyl)-

Product 1

HCID 58007505HCID 58007505, compoundYield 50.3%

Procedure

In analogy to example 9, step 1, 4-methylaniline (298 mg, 2.78 mmol) was coupled to (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (750 mg, 4.03 mmol) to provide the title compound as a pale yellow oil (392 mg, 35%) MS m/e: 281.1 [M+H]+.

Sources & evidence

ORD record
ord-8cb1eeb806b34297a85d6b90126c6bc6
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

Loading…