Trifluoroacetic acid → N-Benzothiazol-6-yl-2-(2-methoxy-phenyl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide

HRID 1094376Notes

Reaction equation

HRID 1094376 reaction equation
C(O)(C(F)(F)F)=O.[S:8]1[C:12]2[CH:13]=[C:14]([NH:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH:15]=[CH:16][C:11]=2[N:10]=[CH:9]1.[CH3:30][O:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[CH2:38][C:39](O)=[O:40]>>[S:8]1[C:12]2[CH:13]=[C:14]([N:17]([CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=3)[C:39](=[O:40])[CH2:38][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=3[O:31][CH3:30])[CH:15]=[CH:16][C:11]=2[N:10]=[CH:9]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 71342-Methoxyphenylacetic acidHCID 57570295Benzothiazol-6-yl-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

Product 1

HCID 57570438N-Benzothiazol-6-yl-2-(2-methoxy-phenyl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide

Procedure

In analogy to example 33, step 2, without TFA addition, benzothiazol-6-yl-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine was coupled to (2-methoxy-phenyl)-acetic acid (commercially available) to provide the title compound. MS m/e: 471.0 [M+H]+.

Sources & evidence

ORD record
ord-1b26131514e54675940b9a07ae7ae50c
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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